RETROGRADE CEREBRAL PERFUSION WITH HYPOTHERMIC BLOOD PROVIDES EFFICIENT PROTECTION OF THE BRAIN - A NEUROPATHOLOGICAL STUDY

被引：15

作者：

IMAMAKI, M

KOYANAGI, H

HASHIMOTO, A

AOMI, S

HACHIDA, M

机构：

[1] Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College, Tokyo

来源：

JOURNAL OF CARDIAC SURGERY | 1995年 / 10卷 / 04期

关键词：

D O I：

10.1111/j.1540-8191.1995.tb00619.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Retrograde cerebral perfusion is a method that is recently being used for protection of the brain during operations on the aortic arch, This method is useful but is said to provide a limited time for protecting the brain. We designed an experiment in dogs to investigate neuropathologically the effect of protecting the brain for 120 minutes under: (1) circulatory arrest (CA); (2) retrograde cerebral perfusion with moderately cooled blood (RCPMC); and (3) retrograde cerebral perfusion with deeply cooled blood (RCPDC). We calculated the number of the abnormal cells of 400 hippocampal neurons per dog light microscopically. The number was 199 +/- 23 (mean +/- 1 SD) in the CA group, 149 +/- 50 in the RCPMC group, and 72 +/- 33 in the RCPDC group. The difference between the CA group and the RCPMC group was not statistically significant (p < 0.05), but there was a significant difference between the RCPMC and RCPDC groups (p < 0.05). The degree of cerebral protection provided by retrograde cerebral perfusion for 120 minutes is not sufficient when using moderately cooled blood, If we use deeply cooled blood at a temperature of about 10 degrees C, we should obtain a sufficient degree of protection of the brain.

引用

页码：325 / 333

页数：9

共 24 条

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