Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit

被引：8

作者：

Claisse, Guillaume ^{[1
]}

Delavenne, Xavier ^{[2
]}

Masson, Ingrid ^{[1
]}

Maillard, Nicolas ^{[1
]}

Alamartine, Eric ^{[1
]}

Mariat, Christophe ^{[1
]}

机构：

[1] Univ Hosp St Etienne, Dept Nephrol, St Priest En Jarez, France

[2] Univ Hosp St Etienne, Dept Pharmacol, St Priest En Jarez, France

来源：

CLINICAL KIDNEY JOURNAL | 2015年 / 8卷 / 02期

关键词：

dabigatran overexposure; haemodiafiltration; haemorrhagic shock; intensive care;

D O I：

10.1093/ckj/sfv001

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Dabigatran is a direct thrombin inhibitor indicated for thromboembolism prophylaxis in patients with non-valvular atrial fibrillation. The procedure to manage dabigatran-associated haemorrhages is not well formalized. Conventional haemodialysis has been evaluated with good results. Patients with dabigatran-associated bleeding may be unstable and convective techniques like venovenous haemodiafiltration (HDF) can be interesting. We report the case of a 74-year-old, critically ill patient with haemorrhagic shock and dabigatran overexposure due to acute kidney injury. He underwent HDF and dabigatran blood concentrations decreased from 325.3 ng/mL to 160.5 ng/mL. We report here key pharmacokinetics parameters (half-life, extraction coefficient, clearance).

引用

页码：199 / 201

页数：3

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