SYNTHESIS AND NONTHROMBOGENICITY OF POLYETHERURETHANEUREA FILM GRAFTED WITH POLY(SODIUM VINYL SULFONATE)

被引：51

作者：

ITO, Y

IGUCHI, Y

KASHIWAGI, T

IMANISHI, Y

机构：

[1] Department of Polymer Chemistry, Kyoto University, Sakyo-Ku, Kyoto, 606, Yoshida Honmachi

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1991年 / 25卷 / 11期

关键词：

D O I：

10.1002/jbm.820251104

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Synthesis of nonthrombogenic materials without using biologically active substances was explored. Poly(sodium vinyl sulfonate) is a water-soluble synthetic polymer and activates antithrombin III to exert nonthrombogenicity that was dependent on the molecular weight. Polyetherurethaneurea film was plasma-treated and graft-polymerized with sodium vinyl sulfonate. The graft film showed excellent in vitro and ex vivo nonthrombogenicity by suppressing interactions with plasma proteins and platelets as well as by inactivating blood-clotting factors.

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页码：1347 / 1361

页数：15

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