SYNTHESIS AND NONTHROMBOGENICITY OF POLYETHERURETHANEUREA FILM GRAFTED WITH POLY(SODIUM VINYL SULFONATE)

被引:51
作者
ITO, Y
IGUCHI, Y
KASHIWAGI, T
IMANISHI, Y
机构
[1] Department of Polymer Chemistry, Kyoto University, Sakyo-Ku, Kyoto, 606, Yoshida Honmachi
来源
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1991年 / 25卷 / 11期
关键词
D O I
10.1002/jbm.820251104
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Synthesis of nonthrombogenic materials without using biologically active substances was explored. Poly(sodium vinyl sulfonate) is a water-soluble synthetic polymer and activates antithrombin III to exert nonthrombogenicity that was dependent on the molecular weight. Polyetherurethaneurea film was plasma-treated and graft-polymerized with sodium vinyl sulfonate. The graft film showed excellent in vitro and ex vivo nonthrombogenicity by suppressing interactions with plasma proteins and platelets as well as by inactivating blood-clotting factors.
引用
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页码:1347 / 1361
页数:15
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