PROGRESSIVE DEMENTIA, WITHOUT CEREBRAL-HEMORRHAGE, IN A PATIENT WITH HEREDITARY CEREBRAL AMYLOID ANGIOPATHY

被引：21

作者：

HAAN, J

BAKKER, E

JENNEKENSSCHINKEL, A

ROOS, RAC

机构：

[1] LEIDEN UNIV HOSP,DEPT NEUROL,2333 AA LEIDEN,NETHERLANDS

[2] LEIDEN UNIV HOSP,DEPT HUMAN GENET,2333 AA LEIDEN,NETHERLANDS

[3] LEIDEN UNIV HOSP,DEPT NEUROPSYCHOL,2333 AA LEIDEN,NETHERLANDS

[4] ST ELIZABETH HOSP,DEPT NEUROL,LEIDERDORP,NETHERLANDS

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 1992年 / 94卷 / 04期

关键词：

HEREDITARY CEREBRAL HEMORRHAGE WITH AMYLOIDOSIS; DUTCH TYPE; AMYLOID ANGIOPATHY; DEMENTIA; ALZHEIMERS DISEASE;

D O I：

10.1016/0303-8467(92)90181-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A now 58-year-old female patient, carrier of the point-mutation in the beta-amyloid gene on chromosome 21 which causes hereditary cerebral hemorrhage with amyloidosis - Dutch type, developed progressive dementia after the age of 55 years. She never suffered from a cerebral hemorrhage. Dementia has been described as a feature of hereditary amyloid angiopathy before, but only in patients who also suffer from strokes. The clinical manifestation of the patient described here underlines the relation between the Dutch type of hereditary amyloid angiopathy and (familial) Alzheimer's disease.

引用

页码：317 / 318

页数：2

共 9 条

[1]

BAKKER E, 1992, IN PRESS AM J HUM GE

[2] SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE [J].