THE LOCAL ANTIINFLAMMATORY ACTION OF DEXAMETHASONE IN THE RAT CARRAGEENAN EDEMA MODEL IS REVERSED BY AN ANTISERUM TO LIPOCORTIN-1

被引：41

作者：

DUNCAN, GS ^{[1
]}

PEERS, SH ^{[1
]}

CAREY, F ^{[1
]}

FORDER, R ^{[1
]}

FLOWER, RJ ^{[1
]}

机构：

[1] ICI PHARMACEUT PLC,BIOSCI 2,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1993年 / 108卷 / 01期

关键词：

LIPOCORTIN-1; DEXAMETHASONE; CARRAGEENAN EDEMA;

D O I：

10.1111/j.1476-5381.1993.tb13440.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 A local pre-injection of 1 mug dexamethasone sodium phosphate strongly inhibited (>60% inhibition at 3 h; P<0.001 at all time points) the development of carrageenin-induced paw oedema in the rat induced by a subplantar injection of 0.1 ml, 2% carrageenin. 2 Coinjection of a polyclonal rabbit antiserum raised against human 1-188 recombinant lipocortin 1, which also recognised the rat protein, reversed the inhibitory action of dexamethasone (P<0.05 at 4 h and 5 h). At the highest volume used (40 mul) control antisera were without any effect. 3 These data further support the concept that lipocortin 1 is involved in the anti-inflammatory mechanism of action of the glucocorticoids.

引用

页码：62 / 65

页数：4

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