OXYGEN-TRANSPORT AND IN-VIVO PARAMETERS OF ARTIFICIAL RED-CELLS (ARC)

被引：7

作者：

AKAMA, K

MORIZAWA, K

TOKUYAMA, S

SATOH, T

KOBAYASHI, K

SEKIGUCHI, S

TSUCHIDA, E

机构：

[1] KEIO UNIV,DEPT SURG,TOKYO 160,JAPAN

[2] HOKKAIDO RED CROSS CTR,CTR BLOOD,SAPPORO,HOKKAIDO 063,JAPAN

[3] WASEDA UNIV,DEPT POLYMER CHEM,TOKYO 169,JAPAN

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY | 1994年 / 22卷 / 03期

关键词：

D O I：

10.3109/10731199409117928

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Artificial red cells (ARC) are prepared by encapsulating Hb with a polymerizable phospholipid. Their physical stability is very high and long-term preservation is possible in the frozen state. We examined the effect of blood parameters on the hematological and biochemical findings in transfused rats. The oxygen transport capacity of ARC in vivo were also tested by exchange transfusion in beagles. The oxygen binding parameters were almost the same as those of red blood cells (i.e., P50, Hill's coefficient, and oxygen transport efficiency (OTE) were 30 mmHg, 2.5, and 30%, respectively). The blood parameters after transfusion showed no significant changes when compared with the control. The oxygen transport capacity was of the same efficiency as red blood cells.

引用

页码：901 / 907

页数：7