SOFT-TISSUE SARCOMA AND NON-HODGKINS-LYMPHOMA IN WORKERS EXPOSED TO PHENOXY HERBICIDES, CHLOROPHENOLS, AND DIOXINS - 2 NESTED CASE-CONTROL STUDIES

被引：123

作者：

KOGEVINAS, M ^{[1
]}

KAUPPINEN, T ^{[1
]}

WINKELMANN, R ^{[1
]}

BECHER, H ^{[1
]}

BERTAZZI, PA ^{[1
]}

BUENODEMESQUITA, HB ^{[1
]}

COGGON, D ^{[1
]}

GREEN, L ^{[1
]}

JOHNSON, E ^{[1
]}

LITTORIN, M ^{[1
]}

LYNGE, E ^{[1
]}

MARLOW, DA ^{[1
]}

MATHEWS, JD ^{[1
]}

NEUBERGER, M ^{[1
]}

BENN, T ^{[1
]}

PANNETT, B ^{[1
]}

PEARCE, N ^{[1
]}

SARACCI, R ^{[1
]}

机构：

[1] INT AGCY RES CANC,LYON,FRANCE

来源：

EPIDEMIOLOGY | 1995年 / 6卷 / 04期

关键词：

SOFT TISSUE SARCOMA; NON-HODGKINS LYMPHOMA; PHENOXY HERBICIDES; DIOXIN; CASE CONTROL STUDY;

D O I：

10.1097/00001648-199507000-00012

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We examined the effect of exposure to chemicals present in the production and spraying of phenoxy herbicides or chlorophenols in two nested case-control studies of soft tissue sarcoma and non-Hodgkin's lymphoma. Eleven sarcoma and 32 lymphoma cases occurring within an international cohere were matched for age, sex, and country of residence with 55 and 158 controls, respectively. Exposures to 21 chemicals or mixtures were estimated by three industrial hygienists who were blind to the subject's case-control status. Excess risk of soft tissue sarcoma was associated with exposure to any phenoxy herbicide [odds ratio (OR) = 10.3; 95% confidence interval (CI) 1.2-91] and to each of the three major classes of phenoxy herbicides (2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, and 4-chloro-2-methylphenoxyacetic acid), to any polychlorinated dibenzodioxin or furan (OR = 5.6; 95% CI = 1.1-28), and to 2,3,7,8-tetrachlorodibenzo-p-dioxin (OR = 5.2; 95% CI = 0.85-32). Sarcoma risk was not associated with exposure to raw materials or other process chemicals. In the non-Hodgkin's lymphoma study, associations were generally weaker than those found in the study on sarcoma. These findings indicate that workers exposed to phenoxy herbicides and their contaminants are at a higher risk of soft tissue sarcoma.

引用

页码：396 / 402

页数：7

共 36 条

[1] IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 41. Some Halogenated Hydrocarbons and Pesticide Exposures, (1986)
[2] Saracci R., Kogevinas M., Bertazzi P.A., Bueno-De-mesquita H.B., Coggon D., Green L.M., Kauppinen T., Lynge E., Mathews J.D., Neuherger M., Osman J., Pearce N., Winkelmann R., Cancer mortality in workers exposed to phenoxy herbicides and chlorophenols, Lancet, 338, pp. 1027-1032, (1991)
[3] Fingerhut M.A., Halpcrin W.E., Marlow D.A., Piacitclli L.A., Honchar P.A., Sweeney M.H., Griefe A.L., Dill P.A., Steenland K., Suruda A.J., Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin, N Engl J Med, 324, pp. 212-218, (1991)
[4] Manz A., Berber J., Dwyer J.H., Flesch-Janys D., Nagel S., Waltsgott H., Cancer mortality among workers in chemical plant contaminated with dioxin, Lancet, 338, pp. 959-964, (1991)
[5] Bertazzi P.A., Pesatori A.C., Consonni D., Tironi A., Landi M.T., Zocchetti C., Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin, Epidemiology, 4, pp. 398-406, (1993)
[6] Johnson E.S., Important aspects of the evidence for TCDD carcinogenicity in man, Environ Health Perspect, 99, pp. 383-390, (1993)
[7] Hoar Zahm S., Weisenburger D.D., Babbitt P.A., Saal R.C., Vaught J.B., Cantor K.P., Blair A., A case-control study of non-Hodgkin’s lymphoma and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in Eastern Nebraska, Epidemiology, 1, pp. 349-356, (1990)
[8] Pearce N., Bethwaite P., Increasing incidence of non-Hodgkin’s lymphoma: Occupational and environmental factors, Cancer Res (suppl), 52, pp. 5496s-5500s, (1992)
[9] Lynge E., Cancer in phenoxy herbicide manufacturing workers in Denmark, 1947–87: An update, Cancer Causes Control, 4, pp. 261-272, (1993)
[10] Hardell L., Eriksson M., Axelson O., Fredriksson M., Dioxin and mortality from cancer (Letter), N Engl J Med, 324, pp. 1810-1811, (1991)

← 1 2 3 4 →