NONSHIVERING THERMOGENESIS DURING PROSTAGLANDIN E(1) FEVER IN RATS - ROLE OF THE CEREBRAL-CORTEX

被引:25
作者
MONDA, M [1 ]
AMARO, S [1 ]
DELUCA, B [1 ]
机构
[1] UNIV NAPLES 2,FAC MED & SURG,DEPT HUMAN PHYSIOL & INTEGRATE BIOL FUNCT FILIPPO,NAPLES,ITALY
关键词
NONSHIVERING THERMOGENESIS; PROSTAGLANDIN E(1); CEREBRAL CORTEX; BROWN ADIPOSE TISSUE; SYMPATHETIC ACTIVITY; OXYGEN CONSUMPTION; BODY TEMPERATURE;
D O I
10.1016/0006-8993(94)90691-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have tested the hypothesis that there is a role for the cerebral cortex in the control of non-shivering thermogenesis during fever induced by prostaglandin E(1) (PGE(1)). While under urethan anesthesia, the firing rate of nerves innervating interscapular brown adipose tissue (IBAT), IBAT and colonic temperatures (T-IBAT and T-c) and oxygen (O-2) consumption were monitored during the fever from PGE(1) injection (400 and 800 ng) in a lateral cerebral ventricle in controls and in functionally decorticated Sprague-Dawley rats. Rats were functionally decorticated by applying 3.3 M KCl solution on the frontal cortex which causes cortical spreading depression (CSD). Pyrogen injections caused dose-related increases in firing rate, T-IBAT, T-c and O-2 consumption and CSD reduced these enhancements. Our findings indicate that the cerebral cortex could be involved in the control of non-shivering thermogenesis during PGE(1)-induced febrile response.
引用
收藏
页码:148 / 154
页数:7
相关论文
共 28 条