AUGMENTED SYMPATHETIC-NERVE ACTIVITY IN RESPONSE TO STRESSORS IN YOUNG BORDERLINE HYPERTENSIVE MEN

被引:93
作者
MATSUKAWA, T
GOTOH, E
UNEDA, S
MIYAJIMA, E
SHIONOIRI, H
TOCHIKUBO, O
ISHII, M
机构
[1] II Department Internal Med., Yokohama City University Med., Minami-ku, Yokohama
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 1991年 / 141卷 / 02期
关键词
BORDERLINE HYPERTENSION; EPINEPHRINE; MICRONEUROGRAPHY; PHYSICAL STRESSOR; PSYCHOLOGICAL STRESSOR; MUSCLE SYMPATHETIC NERVE ACTIVITY;
D O I
10.1111/j.1748-1716.1991.tb09064.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To determine whether there may be an abnormality in sympathetic nerve activity in response to physical and psychological stressors, we microneurologically recorded muscle sympathetic nerve activity in 11 normotensive and 9 borderline hypertensive, age-matched men. Supine blood pressure, plasma levels of epinephrine and norepinephrine and muscle sympathetic nerve activity were measured before and during a cold pressor test or a mental arithmetic test. The resting basal values of muscle sympathetic nerve activity, blood pressure and plasma epinephrine were significantly higher in the borderline hypertensives than in the normotensives (P < 0.05). Plasma norepinephrine levels tended to be higher in the borderline hypertensives than in the normotensives but not to a significant extent (P < 0.10). The cold pressor test produced significantly exaggerated pressor and muscle sympathetic nerve responses (P < 0.05) with a trend towards an increase in plasma norepinephrine (P < 0.10) in the borderline hypertensives as compared with normotensives. The mental arithmetic test produced significantly enhanced pressor and plasma epinephrine responses in the borderline hypertensives as compared with the normotensives (P < 0.05). During the mental arithmetic test the muscle sympathetic nerve activity decreased significantly in the normotensives P(< 0.05) but not in the borderline hypertensives. These findings indicate that in people with borderline hypertension an abnormality exists in sympathetic nerve activity at rest and in response to stressors.
引用
收藏
页码:157 / 165
页数:9
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