ATOMIC MODEL OF THE ACTIN FILAMENT

被引：1360

作者：

HOLMES, KC

POPP, D

GEBHARD, W

KABSCH, W

机构：

[1] Max-Planck-Institut für Medizinische Forschung, Abteilung Biophysik, 6900 Heidelberg

来源：

NATURE | 1990年 / 347卷 / 6288期

关键词：

D O I：

10.1038/347044a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The F-actin filament has been constructed from the atomic structure of the actin monomer to fit the observed X-ray fibre diagram from oriented gels of F-actin. A unique orientation of the monomer with respect to the actin helix has been found. The main interactions are along the two-start helix with a contribution from a loop extending across the filament axis provided by the molecule in the adjacent strand. There are also contacts along the left-handed genetic helix. © 1990 Nature Publishing Group.

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页码：44 / 49

页数：6

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