BIOPSY SPECIMEN IDENTIFICATION BY DETECTION OF SEX-CHROMOSOMES - APPLICATION OF INSITU HYBRIDIZATION

被引：9

作者：

KIBBELAAR, RE

LEENHEERSBINNENDIJK, CF

SPAANDER, PJ

KLUIN, PM

机构：

[1] Laboratory of Pathology, State University Leiden, 2300 RC Leiden

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1992年 / 45卷 / 02期

关键词：

D O I：

10.1136/jcp.45.2.149

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aims: To investigate the feasibility of non-radioactive in situ hybridisation (ISH) for the identification of sex-mismatched plastic embedded bone marrow biopsy specimens. Methods: After a suspected accidental transposition of two glycolmethacrylate embedded bone marrow specimens, in situ hybridisation with sex chromosome specific probes was performed. Results: Quantitative analysis of the hybridisation signals established unequivocably the origin of the specimens. Conclusions: ISH is feasible on GMA embedded bone marrow specimens, and can be used for the identification of accidentally transposed specimens provided that they are of sex-matched origin.

引用

页码：149 / 150

页数：2

共 8 条

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