THYMIC DEPLETION AND PERIPHERAL ACTIVATION OF CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED T-CELLS BY SOLUBLE PEPTIDE IN T-CELL RECEPTOR TRANSGENIC MICE

被引：143

作者：

MAMALAKI, C

NORTON, T

TANAKA, Y

TOWNSEND, AR

CHANDLER, P

SIMPSON, E

KIOUSSIS, D

机构：

[1] JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND

[2] CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 23期

关键词：

D O I：

10.1073/pnas.89.23.11342

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell receptor with a soluble peptide antigen from influenza virus nucleoprotein results in clonal depletion of double-positive immature thymocytes in the thymus and activation of mature T cells in the periphery, accompanied by a transient up-regulation of the T-cell receptor and CD3 and CD8 coreceptor molecules.

引用

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页码：11342 / 11346

页数：5

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