MONOCLONAL-ANTIBODY TO THE TYPE-I INSULIN-LIKE GROWTH-FACTOR (IGF-I) RECEPTOR BLOCKS IGF-I RECEPTOR-MEDIATED DNA-SYNTHESIS - CLARIFICATION OF THE MITOGENIC MECHANISMS OF IGF-I AND INSULIN IN HUMAN-SKIN FIBROBLASTS

被引:279
作者
FLIER, JS
USHER, P
MOSES, AC
机构
[1] BETH ISRAEL HOSP,HARVARD THORNDIKE LAB,BOSTON,MA 02215
[2] BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215
[3] HARVARD UNIV,SCH MED,BOSTON,MA 02115
关键词
D O I
10.1073/pnas.83.3.664
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:664 / 668
页数:5
相关论文
共 40 条
[1]  
BALDWIN D, 1980, J BIOL CHEM, V255, P4028
[2]  
BAXTER RC, 1982, CLIN CHEM, V28, P485
[3]   INSULIN-LIKE GROWTH FACTOR-I/SOMATOMEDIN-C (IGF-I/SM-C) AND GLUCOCORTICOIDS SYNERGISTICALLY REGULATE MITOSIS IN COMPETENT HUMAN-FIBROBLASTS [J].
CONOVER, CA ;
DOLLAR, LA ;
HINTZ, RL ;
ROSENFELD, RG .
JOURNAL OF CELLULAR PHYSIOLOGY, 1983, 116 (02) :191-197
[4]  
CZECH MP, 1983, FED PROC, V42, P2598
[5]   LEPRECHAUNISM - STUDIES OF THE RELATIONSHIP AMONG HYPERINSULINISM, INSULIN RESISTANCE, AND GROWTH-RETARDATION [J].
DERCOLE, AJ ;
UNDERWOOD, LE ;
GROELKE, J ;
PLET, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1979, 48 (03) :495-502
[6]   AUTOANTIBODIES TO INSULIN RECEPTOR - EFFECT ON INSULIN-RECEPTOR INTERACTION IN IM-9 LYMPHOCYTES [J].
FLIER, JS ;
KAHN, CR ;
JARRETT, DB ;
ROTH, J .
JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (04) :784-794
[7]   CHARACTERIZATION OF ANTIBODIES TO INSULIN RECEPTOR - CAUSE OF INSULIN-RESISTANT DIABETES IN MAN [J].
FLIER, JS ;
KAHN, CR ;
JARRETT, DB ;
ROTH, J .
JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (06) :1442-1449
[8]   CHARACTERIZATION OF MONOCLONAL-ANTIBODIES TO THE IGF-I RECEPTOR THAT INHIBIT IGF-I BINDING TO HUMAN-CELLS [J].
FLIER, JS ;
MOSES, AC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 127 (03) :929-936
[9]  
FREYCHET P, 1972, J BIOL CHEM, V247, P3953
[10]  
FROESCH ER, 1985, ANNU REV PHYSIOL, V47, P443