THE SYNTHESIS, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF SOME LONG-CHAIN ACYL CARNITINE ESTERS ON THE CORONARY CIRCULATION OF THE RAT ISOLATED HEART

被引：9

作者：

CRIDDLE, DN ^{[1
]}

DEWAR, GH ^{[1
]}

RADNIKNAM, M ^{[1
]}

WATHEY, WB ^{[1
]}

WOODWARD, B ^{[1
]}

机构：

[1] UNIV BATH,PHARMACOL GRP,BATH BA2 7AY,AVON,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 09期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb03553.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The synthesis of the isopropyl ester of carnitine and a series of fatty acid derivatives with fatty acid lengths C8-C30 is described. Bolus doses of these compounds (0.03-300 nmol) showed coronary vasodilator activity in the rat isolated heart. Increasing fatty acid chain length from C8 to C16 resulted in an increased vasodilator potency. Longer lasting vasodilation was observed with the C20 compound. Increasing fatty acid chain length to C30 was associated with a small dilator response preceded by vasoconstriction.

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页码：636 / 639

页数：4

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