INTERLEUKIN-10 PROTECTS MICE AGAINST STAPHYLOCOCCAL-ENTEROTOXIN B-INDUCED LETHAL SHOCK

被引：152

作者：

BEAN, AGD ^{[1
]}

FREIBERG, RA ^{[1
]}

ANDRADE, S ^{[1
]}

MENON, S ^{[1
]}

ZLOTNIK, A ^{[1
]}

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC,RES INST,DEPT IMMUNOL,901 CALIF AVE,PALO ALTO,CA 94304

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 11期

关键词：

D O I：

10.1128/IAI.61.11.4937-4939.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Treatment of mice with IL-10 prevented the death of mice injected with SEB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or concurrent with SEB but was less effective when administered following SEB injection. This observation indicates that IL-10 is capable of regulating T-cell activation in vivo.

引用

页码：4937 / 4939

页数：3

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