CHANGES IN BRAIN MONOAMINERGIC NEUROTRANSMITTER CONCENTRATIONS IN RAT AFTER INTRACEREBROVENTRICULAR INJECTION OF STREPTOZOTOCIN

被引：35

作者：

DING, A ^{[1
]}

NITSCH, R ^{[1
]}

HOYER, S ^{[1
]}

机构：

[1] UNIV HEIDELBERG,DEPT PATHOCHEM & GEN NEUROCHEM,NEUENHEIMER FELD 220-221,W-6900 HEIDELBERG,GERMANY

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1992年 / 12卷 / 01期

关键词：

BRAIN GLUCOSE METABOLISM; BRAIN INSULIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MONOAMINERGIC NEUROTRANSMITTERS; STREPTOZOTOCIN;

D O I：

10.1038/jcbfm.1992.13

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The tissue concentrations of the monoaminergic neurotransmitters noradrenaline (NA), dopamine, and serotonin (5-HT) and of their major metabolites were measured by HPLC and electrochemical detection in several rat brain areas after intracerebroventricular injection of streptozotocin (STZ). NA levels were found to be decreased in the frontal cortex by 14%, in the entorhinal cortex by 18%, and in the striatum by 38%. In the entorhinal cortex, 5-HT levels were decreased by 19% and the 5-HT turnover rate, measured as the 5-hydroxyindoleacetic acid/5-HT ratio, was found to be increased by 48%. These results may be indicative of a distinct susceptibility of some neurotransmitters in certain brain areas after a more general impairment of brain metabolism by means of intracerebroventricular application of the diabetogenic compound STZ.

引用

页码：103 / 109

页数：7

共 69 条

[1] WHAT IS THE NATURE OF THE ROLE OF THE SEROTONERGIC NERVOUS-SYSTEM IN LEARNING AND MEMORY - PROSPECTS FOR DEVELOPMENT OF AN EFFECTIVE TREATMENT STRATEGY FOR SENILE DEMENTIA [J].

ALTMAN, HJ ;

NORMILE, HJ .

NEUROBIOLOGY OF AGING, 1988, 9 (5-6) :627-638

[2] CENTRALLY MEDIATED HYPOGLYCEMIC EFFECT OF INSULIN - APPARENT INVOLVEMENT OF SPECIFIC INSULIN-RECEPTORS [J].

AMIR, S ;

SHECHTER, Y .

BRAIN RESEARCH, 1987, 418 (01) :152-156

[3] INSULIN IN THE BRAIN [J].

BASKIN, DG ;

FIGLEWICZ, DP ;

WOODS, SC ;

PORTE, D ;

DORSA, DM .

ANNUAL REVIEW OF PHYSIOLOGY, 1987, 49 :335-347

[4] PROTECTION BY THYMIDINE, AN INHIBITOR OF POLYADENOSINE DIPHOSPHATE RIBOSYLATION, OF STREPTOZOTOCIN INHIBITION OF INSULIN-SECRETION [J].

BOLAFFI, JL ;

NAGAMATSU, S ;

HARRIS, J ;

GRODSKY, GM .

ENDOCRINOLOGY, 1987, 120 (05) :2117-2122

[5]

BOYD FT, 1985, J BIOL CHEM, V260, P5880

[6] REDUCTION IN BRAIN-SEROTONIN SYNTHESIS RATE IN STREPTOZOTOCIN-DIABETIC RATS [J].

CRANDALL, EA ;

GILLIS, MA ;

FERNSTROM, JD .

ENDOCRINOLOGY, 1981, 109 (01) :310-312

[7] RAPID METHOD FOR DETERMINATION OF 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOLEACETIC ACID IN SMALL REGIONS OF RAT BRAIN [J].

CURZON, G ;

GREEN, AR .

BRITISH JOURNAL OF PHARMACOLOGY, 1970, 39 (03) :653-&

[8] CEREBRAL BLOOD-FLOW AND METABOLISM IN NORMAL HUMAN AGING, PATHOLOGICAL AGING, AND SENILE DEMENTIA [J].

DASTUR, DK .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1985, 5 (01) :1-9

[9] COMPUTED-TOMOGRAPHY AND POSITRON EMISSION TRANSAXIAL TOMOGRAPHY EVALUATIONS OF NORMAL AGING AND ALZHEIMERS-DISEASE [J].

DELEON, MJ ;

FERRIS, SH ;

GEORGE, AE ;

REISBERG, B ;

CHRISTMAN, DR ;

KRICHEFF, II ;

WOLF, AP .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1983, 3 (03) :391-394

[10] ATP AND BRAIN-FUNCTION [J].

ERECINSKA, M ;

SILVER, IA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (01) :2-19

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