AMYLOID-P COMPONENT PROMOTES AGGREGATION OF ALZHEIMERS BETA-AMYLOID PEPTIDE

被引：39

作者：

HAMAZAKI, H

机构：

[1] Kitasato Univ, Sch Med, Dept Biol, Sagamihara, Kanagawa

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 211卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.1819

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid P component (AP) has been recognized as a beta-amyloid-associated protein but the pathological role is not known. In the present experiments, it has been shown that AP promotes the aggregation of Alzheimer's beta-amyloid peptide (A beta) in the presence of a physiological concentration of Ca2+. The aggregation promotion was observed at a concentration of soluble A beta 1-40 in human cerebrospinal fluid. The results suggest that AP is possibly a pathogenic factor of the cerebral amyloidosis. (C) Academic Press, Inc.

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页码：349 / 353

页数：5

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