ROLE OF TRANSFORMING GROWTH-FACTOR-BETA IN TESTICULAR IMMUNOSUPPRESSION

被引：49

作者：

POLLANEN, P

VONEULER, M

JAHNUKAINEN, K

SAARI, T

PARVINEN, M

SAINIOPOLLANEN, S

SODER, O

机构：

[1] KAROLINSKA INST, RADIUMHEMMET, S-10401 STOCKHOLM 60, SWEDEN

[2] KAROLINSKA INST, PEDIAT ENDOCRINOL UNIT, S-10401 STOCKHOLM 60, SWEDEN

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1993年 / 24卷 / 02期

基金：

芬兰科学院;

关键词：

RAT TESTIS; CRYPTORCHIDISM; IMMUNOSUPPRESSION; GROWTH FACTORS; TRANSFORMING GROWTH FACTOR-BETA;

D O I：

10.1016/0165-0378(93)90015-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The potential role of transforming growth factor beta (TGFbeta) in the regulation of the immunological milieu of the testis was investigated. Antibodies neutralizing TGFbeta reversed the previously observed suppression of rat peripheral blood lymphocyte proliferation induced by rat abdominal testis extract. Recombinant TGFbeta1 dose-dependently inhibited testicular interleukin-1-like factor-driven proliferation of murine thymocytes and ConA-stimulated rat peripheral blood mononuclear cells. Extracts of seminiferous tubules contained a M(r) approximately 25 K TGFbeta-like growth inhibitor of the CLL-64 mink lung epithelial cell line. The present findings suggest an important role for TGFbeta in testicular immunosuppression.

引用

页码：123 / 137

页数：15

共 41 条

[1]

ALEXANDER NJ, 1987, FERTIL STERIL, V47, P192

[2]

AVALLET O, 1992, 7TH EUR WORKSH MOL C, P81

[3]

CLARK DA, 1990, J IMMUNOL, V144, P3008

[4]

COHEN JHM, 1983, J IMMUNOL, V131, P2767