TOPICAL CALCIPOTRIOL TREATMENT IN ADVANCED BREAST-CANCER

被引：110

作者：

BOWER, M

COLSTON, KW

STEIN, RC

HEDLEY, A

GAZET, JC

FORD, HT

COOMBES, RC

机构：

[1] ST GEORGE HOSP,SCH MED,DEPT CELLULAR & MOLEC BIOL,CLIN ONCOL UNIT,LONDON,ENGLAND

[2] ST GEORGE HOSP,SCH MED,DEPT CLIN BIOCHEM,LONDON,ENGLAND

[3] ST GEORGE HOSP,COMBINED BREAST CLIN,LONDON,ENGLAND

来源：

LANCET | 1991年 / 337卷 / 8743期

关键词：

D O I：

10.1016/0140-6736(91)90280-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

19 patients with locally advanced or cutaneous metastatic breast cancer were treated with the topical vitamin D analogue calcipotriol 100-mu-g daily. 14 patients completed 6 weeks' treatment; 3 showed a 50% reduction in the bidimensional diameter of treated lesions and 1 other patient showed a minimal response. 2 patients became hypercalcaemic during treatment. In all patients who responded the tumours contained receptors for 1,25-dihydroxyvitamin D3, shown by immunocytochemistry.

引用

页码：701 / 702

页数：2

共 11 条

[1] IMMUNOCYTOCHEMICAL DETECTION OF 1,25-DIHYDROXYVITAMIN-D RECEPTORS IN NORMAL HUMAN-TISSUES [J].