EFFECTS OF CHANGES IN THE PERIPHERY ON DEVELOPMENT OF THE CORTICOSPINAL MOTOR SYSTEM IN THE RAT

被引:19
作者
HUTTENLOCHER, PR
BONNIER, C
机构
[1] UNIV CHICAGO,DEPT NEUROL,CHICAGO,IL 60637
[2] UNIV CHICAGO,COMMITTEE NEUROBIOL,CHICAGO,IL 60637
来源
DEVELOPMENTAL BRAIN RESEARCH | 1991年 / 60卷 / 02期
关键词
PLASTICITY; CORTICOSPINAL SYSTEM; LIMB RESTRAINT; CORTICAL LOCALIZATION;
D O I
10.1016/0165-3806(91)90054-M
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Effects of changes in the periphery on development of the corticospinal (CS) motor system were studied in the rat. Unilateral forelimb restraint between ages 5 and 30 days resulted in an increase in the number of CS neurons which persisted in the adult. The effect was most marked ipsilateral to limb restraint where both crossed and uncrossed CS connections were increased, but it also occurred to a lesser extent on the contralateral side. Animals with limb restraint had enlargement of the areas of cerebral cortex in which CS neurons occurred. The enlargement of motor cortex regions and increase in CS neurons closely resembled the changes found in the remaining cerebral hemisphere after neonatal hemispherectomy. The findings in animals with forelimb restraint differed markedly from those after forelimb amputation, where little change occurred in either number or location of CS neurons. Limb restraint initiated at the time of postnatal hemispherectomy had no effects on location or number of CS neurons beyond those of hemispherectomy alone. It is proposed that transient CS axons that occur normally in the postnatal rat may be recruited for formation of permanent connections under very diverse conditions, i.e. hemispherectomy and limb restraint. Failure to observe an additional effect of limb restraint in hemispherectomized animals may due to the fact that after hemispherectomy all available transient fibers in the remaining hemisphere are recruited for innervation of the side of the spinal cord that has lost its cortical input.
引用
收藏
页码:253 / 260
页数:8
相关论文
共 37 条
[1]   A TRANSIENT COMPONENT OF THE DEVELOPING CORTICOSPINAL TRACT ARISES IN VISUAL-CORTEX [J].
ADAMS, CE ;
MIHAILOFF, GA ;
WOODWARD, DJ .
NEUROSCIENCE LETTERS, 1983, 36 (03) :243-248
[2]  
BARTH TM, 1990, J NEUROSCI, V10, P3449
[3]   THE EMERGENCE OF A DISCRETELY DISTRIBUTED PATTERN OF CORTICOSPINAL PROJECTION NEURONS [J].
BATES, CA ;
KILLACKEY, HP .
DEVELOPMENTAL BRAIN RESEARCH, 1984, 13 (02) :265-273
[4]  
BAULAC M, 1983, EXP BRAIN RES, V50, P107
[5]   POLYNEURONAL INNERVATION OF SKELETAL-MUSCLE IN NEWBORN RATS AND ITS ELIMINATION DURING MATURATION [J].
BROWN, MC ;
JANSEN, JKS ;
VANESSEN, D .
JOURNAL OF PHYSIOLOGY-LONDON, 1976, 261 (02) :387-&
[6]   EVIDENCE FOR A MULTIPLE INNERVATION OF PURKINJE-CELLS BY CLIMBING FIBERS IN IMMATURE RAT CEREBELLUM [J].
CREPEL, F ;
MARIANI, J ;
DELHAYEBOUCHAUD, N .
JOURNAL OF NEUROBIOLOGY, 1976, 7 (06) :567-578
[7]   NORMAL DEVELOPMENT AND POSTTRAUMATIC PLASTICITY OF CORTICOSPINAL NEURONS IN RATS [J].
DAMATO, CJ ;
HICKS, SP .
EXPERIMENTAL NEUROLOGY, 1978, 60 (03) :557-569
[8]  
DONOGHUE JP, 1988, J NEUROSCI, V8, P3221
[9]  
DONOGHUE JP, 1990, EXP BRAIN RES, V79, P492
[10]   CORTICOSPINAL NEURONS 25 WEEKS AFTER RIGHT HINDLIMB AMPUTATION [J].
FERINGA, ER ;
VAHLSING, HL .
EXPERIMENTAL NEUROLOGY, 1986, 92 (02) :398-403