ACCESSORY CELL-DERIVED SIGNALS REQUIRED FOR T-CELL ACTIVATION

被引:41
作者
JOHNSON, JG [1 ]
JENKINS, MK [1 ]
机构
[1] UNIV MINNESOTA,DEPT MICROBIOL,BOX 196 UMHC,420 DELAWARE ST SE,MINNEAPOLIS,MN 55455
关键词
T-CELL ACTIVATION; ANTIGEN-PRESENTING CELLS; ANERGY; COSTIMULATORY SIGNALS; CD28;
D O I
10.1007/BF02918368
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Various populations of accessory cells differ in their abilities to function as effective antigen-presenting cells (APC) and stimulate CD4+ T cells to produce interleukin-2. Three important factors directly related to APC potency are the expression of class II major histocompatibility complex molecules and the ability to present peptide antigens to the T cell antigen receptor, the expression of costimulatory ligands which deliver important activation signals independent of T cell receptor occupancy and the expression of adhesion molecules which promote conjugate formation so that these activation signals can be effectively delivered to the T cells. The relative importance of these accessory cell functions in T cell activation will be discussed, with an emphasis on costimulation and the CD28/B7 receptor/ligand pair. The consequence of inadequate costimulation by an otherwise effective APC in inducing T cell anergy will also be discussed.
引用
收藏
页码:48 / 64
页数:17
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