SERUM LEVELS OF SOLUBLE E-SELECTIN (ELAM-1) IN IMMUNE-MEDIATED NEUROPATHIES

被引:35
作者
HARTUNG, HP
REINERS, K
MICHELS, M
HUGHES, RAC
HEIDENREICH, F
ZIELASEK, J
ENDERS, U
TOYKA, KV
机构
[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,LONDON SE1 9RT,ENGLAND
[2] GUYS HOSP,DEPT NEUROL,LONDON,ENGLAND
[3] UNIV DUSSELDORF,DEPT NEUROL,W-4000 DUSSELDORF,GERMANY
关键词
D O I
10.1212/WNL.44.6.1153
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Adhesion molecules are critically involved in inflammatory responses. We studied serum concentrations of the soluble form of E-selectin (endothelial-leukocyte adhesion molecule-1, ELAM-1) in 187 patients with neuropathies of diverse etiology, 54 patients with other noninflammatory, nondemyelinating neurologic disorders, and 15 healthy controls. Serum E-selectin levels, quantitated by a two-site enzyme-linked immunosorbent assay, were significantly increased in 126 patients with Guillain-Barre syndrome (GBS) (mean +/- SD, 45.1+/-16.3 ng/ml) and 13 patients with vasculitic neuropathies (47.1+/-19.1 ng/ml) compared with patients with other neurologic diseases (19.8+/-7.4 ng/ml) and healthy controls (21.9+/-8.1 ng/ml). In GBS, E-selectin levels were temporally related to disease activity. Cytokine-mediated upregulation of E-selectin may be important in homing and attachment of leukocytes to endoneurial endothelial cells. Raised E-selectin concentrations probably reflect endothelial cell activation occurring early in the sequence of immunopathologic events culminating in peripheral nerve damage.
引用
收藏
页码:1153 / 1158
页数:6
相关论文
共 44 条
[1]   THE ATTRACTION OF ADHESION MOLECULES [J].
ANTEL, JP ;
OWENS, T .
ANNALS OF NEUROLOGY, 1993, 34 (02) :123-124
[2]   SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) ANTIGEN IN PATIENTS WITH RHEUMATOID-ARTHRITIS [J].
AOKI, S ;
IMAI, K ;
YACHI, A .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1993, 38 (05) :485-490
[3]   SUPPRESSION OF EXPERIMENTAL ALLERGIC NEURITIS BY AN ANTIBODY TO THE INTERCELLULAR-ADHESION MOLECULE ICAM-1 [J].
ARCHELOS, JJ ;
MAURER, M ;
JUNG, S ;
TOYKA, KV ;
HARTUNG, HP .
BRAIN, 1993, 116 :1043-1058
[4]   ASSESSMENT OF CURRENT DIAGNOSTIC-CRITERIA FOR GUILLAIN-BARRE-SYNDROME [J].
ASBURY, AK ;
CORNBLATH, DR .
ANNALS OF NEUROLOGY, 1990, 27 :S21-S24
[5]   IMMUNOELECTRONMICROSCOPIC DEMONSTRATION OF MAJOR HISTOCOMPATIBILITY CLASS-II ANTIGEN - EXPRESSION ON ENDOTHELIAL AND PERIVASCULAR CELLS BUT NOT SCHWANN-CELLS IN HUMAN NEUROPATHY [J].
ATKINSON, PF ;
PERRY, ME ;
HALL, SM ;
HUGHES, RAC .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1993, 19 (01) :22-30
[6]   CLINICAL CORRELATION WITH SERUM-SOLUBLE INTERLEUKIN-2 RECEPTOR LEVELS IN GUILLAIN-BARRE-SYNDROME [J].
BANSIL, S ;
MITHEN, FA ;
COOK, SD ;
SHEFFET, A ;
ROHOWSKYKOCHAN, C .
NEUROLOGY, 1991, 41 (08) :1302-1305
[7]   ELEVATED NEOPTERIN LEVELS IN GUILLAIN-BARRE-SYNDROME - FURTHER EVIDENCE OF IMMUNE ACTIVATION [J].
BANSIL, S ;
MITHEN, FA ;
SINGHAL, BS ;
COOK, SD ;
ROHOWSKYKOCHAN, C .
ARCHIVES OF NEUROLOGY, 1992, 49 (12) :1277-1280
[8]   ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULES [J].
BEVILACQUA, MP .
ANNUAL REVIEW OF IMMUNOLOGY, 1993, 11 :767-804
[9]   SELECTINS [J].
BEVILACQUA, MP ;
NELSON, RM .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (02) :379-387
[10]  
CANELLA B, 1990, J EXP MED, V172, P1521