COEXPRESSION OF PLATELET-DERIVED GROWTH FACTOR-B (PDGF) CHAIN AND PDGF-B-TYPE RECEPTOR IN HUMAN GLIOMAS

被引：27

作者：

MAURO, A ^{[1
]}

BULFONE, A ^{[1
]}

TURCO, E ^{[1
]}

SCHIFFER, D ^{[1
]}

机构：

[1] UNIV TURIN,DEPT GENET BIOL & MED CHEM,I-10126 TURIN,ITALY

来源：

CHILDS NERVOUS SYSTEM | 1991年 / 7卷 / 08期

关键词：

GLIOMAS; ONCOGENES; ENDOTHELIAL CELLS;

D O I：

10.1007/BF00263184

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study we analyzed the expression of mRNA for PDGF-B and PDGF B-type receptor (PDGFrecB) in 42 biopsy specimens from human astrocytic gliomas and other brain tumors. All gliomas expressed PDGF-B mRNA at higher levels than found in peritumoral and normal nervous tissues. Levels of PDGF-B transcripts correlated strongly with those of mRNA for glial fibrillary acidic protein. Thus, the production of PDGF-B mRNA may be attributed mainly to tumoral glial cells. PDGFrecB transcripts were found in 24 out of 29 gliomas, in agreement with the hypothesis of an autocrine growth stimulation in these tumors. Moreover, mean levels of PDGFrecB expression were higher in glioblastomas than in astrocytomas and over 30-fold higher in meningiomas than in gliomas. This suggests that in gliomas PDGFrecB can be expressed also by vascular elements, in agreement with the hypothesized existence of a paracrine mechanism that may be responsible for the endothelial hyperplasias.

引用

页码：432 / 436

页数：5

共 26 条

[1] EXPRESSION OF THE SIS GENE BY ENDOTHELIAL-CELLS IN CULTURE AND INVIVO [J].

BARRETT, TB ;

GAJDUSEK, CM ;

SCHWARTZ, SM ;

MCDOUGALL, JK ;

BENDITT, EP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (21) :6772-6774

[2] CDNA CLONING AND EXPRESSION OF THE HUMAN A-TYPE PLATELET-DERIVED GROWTH-FACTOR (PDGF) RECEPTOR ESTABLISHES STRUCTURAL SIMILARITY TO THE B-TYPE PDGF RECEPTOR [J].

CLAESSONWELSH, L ;

ERIKSSON, A ;

WESTERMARK, B ;

HELDIN, CH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) :4917-4921

[3] CDNA CLONING AND EXPRESSION OF A HUMAN PLATELET-DERIVED GROWTH-FACTOR (PDGF) RECEPTOR SPECIFIC FOR B-CHAIN-CONTAINING PDGF MOLECULES [J].

CLAESSONWELSH, L ;

ERIKSSON, A ;

MOREN, A ;

SEVERINSSON, L ;

EK, B ;

OSTMAN, A ;

BETSHOLTZ, C ;

HELDIN, CH .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (08) :3476-3486

[4]

DALLAFAVERA R, 1981, NATURE, V292, P31

[5] CULTURED ENDOTHELIAL-CELLS PRODUCE A PLATELET-DERIVED GROWTH FACTOR-LIKE PROTEIN [J].

DICORLETO, PE ;

BOWENPOPE, DF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (07) :1919-1923

[6] SIMIAN SARCOMA-VIRUS ONC GENE, V-SIS, IS DERIVED FROM THE GENE (OR GENES) ENCODING A PLATELET-DERIVED GROWTH-FACTOR [J].

DOOLITTLE, RF ;

HUNKAPILLER, MW ;

HOOD, LE ;

DEVARE, SG ;

ROBBINS, KC ;

AARONSON, SA ;

ANTONIADES, HN .

SCIENCE, 1983, 221 (4607) :275-277

[7] CLONING AND EXPRESSION OF A CDNA CODING FOR THE HUMAN PLATELET-DERIVED GROWTH-FACTOR RECEPTOR - EVIDENCE FOR MORE THAN ONE RECEPTOR CLASS [J].

GRONWALD, RGK ;

GRANT, FJ ;

HALDEMAN, BA ;

HART, CE ;

OHARA, PJ ;

HAGEN, FS ;

ROSS, R ;

BOWENPOPE, DF ;

MURRAY, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (10) :3435-3439

[8]

HELDIN C-H, 1986, Cancer Reviews, V2, P34

[9] PLATELET-DERIVED GROWTH-FACTOR - 3 ISOFORMS AND 2 RECEPTOR TYPES [J].

HELDIN, CH ;

WESTERMARK, B .

TRENDS IN GENETICS, 1989, 5 (04) :108-111

[10] ENDOTHELIAL-CELL HYPERPLASIA IN HUMAN GLIOBLASTOMA - COEXPRESSION OF MESSENGER-RNA FOR PLATELET-DERIVED GROWTH-FACTOR (PDGF) B-CHAIN AND PDGF RECEPTOR SUGGESTS AUTOCRINE GROWTH-STIMULATION [J].

HERMANSSON, M ;

NISTER, M ;

BETSHOLTZ, C ;

HELDIN, CH ;

WESTERMARK, B ;

FUNA, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) :7748-7752

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