STRAIGHTFORWARD HOMOCHIRAL SYNTHESIS OF THE LACTONE MOIETY OF MEVINIC ACIDS

被引：19

作者：

FRANCE, CJ ^{[1
]}

MCFARLANE, IM ^{[1
]}

NEWTON, CG ^{[1
]}

PITCHEN, P ^{[1
]}

WEBSTER, M ^{[1
]}

机构：

[1] RHONE POULENC RORER LTD,DAGENHAM RES CTR,RAINHAM RD S,DAGENHAM RM10 7XS,ESSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 10期

关键词：

TRIPHENYLPHOSPHINE HYDROBROMIDE; MEVINIC ACID; 2-DEOXY SUGARS;

D O I：

10.1016/0040-4039(93)85028-U

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new straightforward synthesis of the common lactone moiety of mevinic acids is described starting from tri-O-acetyl-D-glucal 2. The key diastereoselective O-glycosidation of 2 with methanol and subsequent methanolysis and tritylation are incorporated in a simple and efficient one-pot process.

引用

页码：1635 / 1638

页数：4

共 25 条

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