EFFECTS OF DEXAMETHASONE ON THE HEPATIC CYTOCHROME-P(450) IIIA SUBFAMILY IN 2 HAMSTER STRAINS MESOCRICETUS-AURATUS AND CRICETUS GRISEUS

被引：11

作者：

ANTIGNAC, E ^{[1
]}

FUKUHARA, M ^{[1
]}

KIMURA, M ^{[1
]}

机构：

[1] NATL INST PUBL HLTH,DEPT VET PUBL HLTH,TOKYO 108,JAPAN

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1993年 / 104卷 / 03期

关键词：

D O I：

10.1016/0742-8413(93)90014-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Administration of dexamethasone significantly reduced the amount of hepatic cytochrome P450 in Syrian golden and Chinese hamsters, while it increased the amount in rats. 2. In contrast to rats, the induction rate of the activities of erythromycin and troleandomycin N-demethylases by dexamethasone was relatively low, while that of the testosterone 6beta-hydroxylase was high in the two hamster strains. 3. Western blot analysis revealed that dexamethasone did not modify markedly the pattern of the P450IIIA subfamily proteins in the two hamster strains.

引用

页码：433 / 437

页数：5

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