EXTRACELLULAR DOMAIN OF THE BOSS TRANSMEMBRANE LIGAND ACTS AS AN ANTAGONIST OF THE SEV RECEPTOR

被引：38

作者：

HART, AC ^{[1
]}

KRAMER, H ^{[1
]}

ZIPURSKY, SL ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,DEPT BIOL CHEM,HOWARD HUGHES MED INST,LOS ANGELES,CA 90024

来源：

NATURE | 1993年 / 361卷 / 6414期

关键词：

D O I：

10.1038/361732a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

THE fate of the R7 photoreceptor cell in the Drosophila compound eye is established by a specific inductive interaction between the R8 photoreceptor neuron and the R7 precursor cell1. This induction is mediated by two cell-surface proteins: the ligand, bride of sevenless2 (boss), and sevenless (sev), a tyrosine-kinase receptor3-5 The structure of boss is unique for a ligand of a tyrosine-kinase receptor. It contains a large extracellular domain, seven transmembrane segments, and a carboxy-terminal cytoplasmic tail6,7. Here we report that: (1) boss activates tyrosine phosphorylation of the sev receptor; (2) the seven transmembrane domain of boss is necessary for its function; and (3) a soluble form of boss acts as an antagonist of the sev receptor both in vivo and in vitro.

引用

页码：732 / 736

页数：5

共 21 条

[1]

ANKELESARIA P, 1990, P NATL ACAD SCI USA, V87, P3289

[2]

THE SEVENLESS+ PROTEIN IS EXPRESSED APICALLY IN CELL-MEMBRANES OF DEVELOPING DROSOPHILA RETINA - IT IS NOT RESTRICTED TO CELL R7 [J].