ALLERGEN-INDUCED CHANGES IN BONE-MARROW PROGENITORS AND AIRWAY RESPONSIVENESS IN DOGS

被引：7

作者：

DENBURG, JA ^{[1
]}

WOOLLEY, MJ ^{[1
]}

ELLIS, R ^{[1
]}

DAHLBACK, M ^{[1
]}

OBYRNE, PM ^{[1
]}

机构：

[1] ASTRO DRACO AB,LUND,SWEDEN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

ALLERGEN; HEMATOPOIESIS GRANULOCYTE MACROPHAGE-COLONY-FORMING CELLS; CORTICOSTEROIDS; ASTHMA;

D O I：

10.1159/000236990

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

An increased production of inflammatory cell progenitors (colony-forming cells, CFUs) may contribute to airway inflammation, since CFUs increase after allergen inhalation in asthmatics. We examined the effect of allergen inhalation, with or without budesonide pretreatment, on bone marrow CFU production in dogs with allergen-induced airway hyperresponsiveness. Allergen inhalation increased airway responsiveness (p<0.001) as well as the number of CFUs induced in vitro by recombinant canine stem cell factor (p<0.001) and granulocyte-colony-stimulating factor (p=0.035). Budesonide reduced the allergen-induced increases in airway responsiveness (p=0.005) and abolished the allergen-induced increases in the numbers of CFUs (p<0.005). These findings provide the first direct evidence that allergen inhalation increases bone marrow granulocyte progenitor production and suggest that such increases may contribute to the development of airway hyperresponsiveness in asthma. The effectiveness of inhaled corticosteroids in asthma may result, in part, from effect on bone marrow production of inflammatory cells.

引用

页码：239 / 241

页数：3

共 14 条

[1]

Dunnill M.S., The pathology of asthma with special reference to changes in the bronchial mucosa, J Clin Pathol, 13, pp. 27-32, (1960)

[2]

Dunnill M.S., Massarella G.R., Erson J.A., A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis and emphysema, Thorax, 24, pp. 176-179, (1969)

[3]

Brusasco V., Crimi E., Gianiorio P., Lantero S., Rossi G.A., Allergen-induced increase in airway responsiveness and inflammation in mild asthma, J Appl Physiol, 69, pp. 2209-2214, (1990)

[4]

Smith H.R., Larsen G.L., Cherniack R.M., Wenzel S.E., Voelkel N.F., Westcott J.Y., Bethel R.A., Inflammatory cells and eicosanoid mediators in subjects with late asthmatic responses and increases in airway responsiveness, J Allergy Clin Immunol, 89, pp. 1076-1084, (1992)

[5]

Bousquct J., Chancz P., Yves Lacoste J., Bameon G., Ghavanian N., Enander I., Venge P., Ahlstedt S., Simony-Lafontaine J., Godard P., Michel F., Eo-sinophilic inflammation in asthma, N Engl J Med, 323, pp. 1033-1039, (1990)

[6]

Wardlaw A.J., Dunnette S., Gleich G.J., Collins J.V., Kay A.B., Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma, Am Rev Respir Dis, 137, pp. 62-69, (1988)

[7]

Azzawi M., Bradley B., Jeffery P.K., Frew A.J., Wardlaw A.J., Knowles G., Assoufi B., Collins J.V., Durham S., Kay A.B., Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma, Am Rev Rcspir Dis, 142, pp. 1407-1413, (1990)

[8]

Kirby J.F., Hargraeve F.E., Gleich G.J., O'byrnc P.M., Bronchoalveolarcell profiles of asthmatics and nonasthmatic subjects, Am Rev Respir Dis, 136, pp. 379-383, (1987)

[9]

Denburg J.A., Harnish D.J., D: Basophil mast cell and eosinophil growth and differentiation factors in human allergic disease, Clin Exp Allergy, 19, pp. 249-254, (1989)

[10]

Gibson P.G., Manning P.J., O'Byrnc P.M., Girgisgabardo A., Dolovich J., Denburg J.A., Hargraeve F.E., Allergen-induced asthmatic responses: Re-lationship between increases in airway respon-siveness and increases in circulating eosinophils, basophils, and their progenitors, Am Rev Respir Dis, 143, pp. 331-335, (1991)

← 1 2 →