EFFECTS OF PARATHYROID-HORMONE AND CALCITONIN ON ALKALINE-PHOSPHATASE ACTIVITY AND MATRIX CALCIFICATION IN RABBIT GROWTH-PLATE CHONDROCYTE CULTURES

被引：58

作者：

KATO, Y ^{[1
]}

SHIMAZU, A ^{[1
]}

NAKASHIMA, K ^{[1
]}

SUZUKI, F ^{[1
]}

JIKKO, A ^{[1
]}

IWAMOTO, M ^{[1
]}

机构：

[1] OSAKA UNIV,FAC DENT,DEPT RADIOL,SUITA,OSAKA 565,JAPAN

来源：

ENDOCRINOLOGY | 1990年 / 127卷 / 01期

关键词：

D O I：

10.1210/endo-127-1-114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of PTH and calcitonin (CT) on the expression of mineralization-related phenotypes by chrondro- cytes were examined. In cultures of pelleted growth-plate chon-drocytes. PTH caused 60-90% decreases in alkaline phosphatase activity, the incorporation of45Ca into insoluble material, and the calcium content during the post-mitotic stage. These effects of PTH were dose-dependent and reversible. In contrast, CT increased alkaline phosphatase activity, 45Ca incorporation into insoluble material, and the calcium content by 1.4- to 1.8-fold. These observations suggest that PTH directly inhibits the expression of the mineralization-related phenotypes by growth- plate chondrocytes, and that CT has the opposite effects. © 1990 by The Endocrine Society.

引用

页码：114 / 118

页数：5

共 31 条

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