SALIVARY-GLAND EXTRACTS FROM THE DEERFLY CONTAIN A POTENT INHIBITOR OF PLATELET-AGGREGATION

被引：27

作者：

GREVELINK, SA

YOUSSEF, DE

LOSCALZO, J

LERNER, EA

机构：

[1] MASSACHUSETTS GEN HOSP,CUTANEOUS BIOL RES CTR,E BLDG 149,13TH ST,BOSTON,MA 02129

[2] BRIGHAM & WOMENS HOSP,DIV CARDIOVASC,BOSTON,MA 02115

[3] VET ADM MED CTR W ROXBURY,BOSTON,MA 02132

[4] HARVARD UNIV,SCH MED,DEPT DERMATOL,BOSTON,MA 02115

[5] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 19期

关键词：

DISINTEGRIN; FIBRINOGEN RECEPTOR; APYRASE; GLYCOPROTEIN-IIB/IIIA;

D O I：

10.1073/pnas.90.19.9155

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Salivary gland extracts of the deerfly contain a potent inhibitor of platelet aggregation, which assists the insect in obtaining a blood meal. The extract prevents platelet aggregation induced by ADP, thrombin, and collagen and inhibits fibrinogen binding to the glycoprotein IIb/IIIa receptor on platelets. The active component in deerfly salivary gland extract appears to be a protein that is comparatively more potent than the disintegrins present in viper venoms. Isolation and characterization of this protein may provide different directions in therapeutics and studies of normal platelet physiology.

引用

页码：9155 / 9158

页数：4

共 18 条

[1] BANG NU, 1990, CIRCULATION, V84, P436
[2] CHARACTERIZATION OF AN ATP DIPHOSPHOHYDROLASE (EC 3.6.1.5) IN SYNAPTOSOMES FROM CEREBRAL-CORTEX OF ADULT-RATS
BATTASTINI, AMO
DAROCHA, JBT
BARCELLOS, CK
DIAS, RD
SARKIS, JJF
[J]. NEUROCHEMICAL RESEARCH, 1991, 16 (12) : 1303 - 1310
[3] BORN GVR, 1963, J PHYSIOL-LONDON, V168, P178, DOI 10.1113/jphysiol.1963.sp007185
[4] NEW APPROACHES TO ANTIPLATELET THERAPY
EZRATTY, AM
LOSCALZO, J
[J]. BLOOD COAGULATION & FIBRINOLYSIS, 1991, 2 (02) : 317 - 327
[5] GOULD RJ, 1990, P SOC EXP BIOL MED, V195, P168, DOI 10.3181/00379727-195-43129B
[6] ASSAY OF INORGANIC AND ORGANIC PHOSPHORUS IN 0.1-5 NANOMOLE RANGE
HESS, HH
DERR, JE
[J]. ANALYTICAL BIOCHEMISTRY, 1975, 63 (02) : 607 - 613
[7] JACOBS JW, 1990, THROMB RES, V15, P869
[8] LERNER EA, 1992, J BIOL CHEM, V267, P1062
[9] LERNER EA, 1991, J BIOL CHEM, V266, P11234
[10] VONWILLEBRAND PROTEIN FACILITATES PLATELET INCORPORATION IN POLYMERIZING FIBRIN
LOSCALZO, J
INBAL, A
HANDIN, RI
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (04) : 1112 - 1119

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