RESTORATION OF TESTICULAR TRANSFERRIN, INSULIN-LIKE GROWTH-FACTOR-I (IGF-1), AND SPERMATOGENESIS BY EXOGENOUSLY ADMINISTERED PURIFIED FSH AND TESTOSTERONE IN MEDICALLY HYPOPHYSECTOMIZED RATS

被引：15

作者：

ITOH, N

NANBU, A

TACHIKI, H

AKAGASHI, K

NITTA, T

MIKUMA, N

TSUKAMOTO, T

KUMAMOTO, Y

机构：

[1] Department of Urology, Sapporo Medical University School of Medicine, Sapporo

来源：

ARCHIVES OF ANDROLOGY | 1994年 / 33卷 / 03期

关键词：

TRANSFERRIN; INSULIN-LIKE GROWTH FACTOR-I; SPERMATOGENESIS; HYPOPHYSECTOMIZED RATS;

D O I：

10.3109/01485019408987821

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

To investigate the relation between testicular transferrin and insulin-like growth factor-1 (IGF-I) secreted by Sertoli cells and the differentiation of germ cells in the rat, testosterone and/or purified FSH was administered to rats medically hypophysectomized by an LH-RH agonist. Spermatogenesis was quantitatively analyzed and concentrations of intratesticular transferrin and IGF-1 were measured by radioimmunoassays. The last step of spermatogenesis was quantitatively restored by combined administration of testosterone and purified FSH. intratesticular IGF-1 concentrations were significantly increased by combined administration of testosterone and purified FSH. From these observations, it is surmised that IGF-1 may have a stimulatory effect on the last step of spermatogenesis.

引用

页码：169 / 177

页数：9

共 21 条

[1] RESTORATION OF SPERMATOGENESIS BY EXOGENOUSLY ADMINISTERED TESTOSTERONE IN RATS MADE AZOOSPERMIC BY HYPOPHYSECTOMY OR WITHDRAWAL OF LUTEINIZING-HORMONE ALONE [J].