New backbone cyclic substance P analogs

被引：7

作者：

Bitan, G

Behrens, S

Matha, B

Mashriki, Y

Hanani, M

Kessler, H

Gilon, C

机构：

[1] HEBREW UNIV JERUSALEM,DEPT ORGAN CHEM,IL-91904 JERUSALEM,ISRAEL

[2] TECH UNIV MUNICH,INST ORGAN CHEM,D-85747 GARCHING,GERMANY

[3] HADASSAH UNIV HOSP,EXPTL SURG LAB,IL-91240 JERUSALEM,ISRAEL

来源：

LETTERS IN PEPTIDE SCIENCE | 1995年 / 2卷 / 3-4期

关键词：

backbone cyclization; substance P; NMR; molecular dynamics; conformational analysis;

D O I：

10.1007/BF00119137

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structure-activity relationships of cyclic substance P (SP) analogs were extensively studied in our laboratories utilizing the new concept of backbone cyclization. Employing the C-terminal hexapeptide SP6-11, we examined the influence of chemical changes in peptides containing backbone-to-amino-end cyclization. These changes in the ring have significant influence on activity, and should be carefully designed in order to optimize pharmacological features.

引用

页码：121 / 124

页数：4

共 12 条

[1]

BITAN G, 1995, TETRAHEDRON, V51, P10513

[2] BUILDING UNITS FOR N-BACKBONE CYCLIC-PEPTIDES .1. SYNTHESIS OF PROTECTED N-(OMEGA-AMINOALKYLENE)AMINO ACIDS AND THEIR INCORPORATION INTO DIPEPTIDE UNITS [J].