A NEW SYNTHESIS OF PYRAZINO[2,3-C]ISOQUINOLINES

被引：7

作者：

BATES, MRM

DEADY, LW

MACKAY, MF

机构：

[1] Chemistry Department, La Trobe University, Bundoora, VIC

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 01期

关键词：

D O I：

10.1071/CH9900179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient synthesis of l-(p-chlorophenoxy)isoquinoline-3, 4-diamine is described. Condensation with ethyl pyruvate gave entry to the tricyclic title system, and some further nucleophilic displacement reactions of substituent groups are described. The direction of ring closure in the tricycle formation was proved by determining the crystal structure of one of the derivatives; rhombohedral crystals of (3b) belong to the space group R3 with a 21 · 822(5) ì a 116·81(2)° and Z 12. Full-matrix refinement using 3093 reflections converged at R 0·085. © 1990 ASEG.

引用

页码：179 / 184

页数：6

共 10 条

[1]

Cheeseman G.W.H., 1979, CHEM HETEROCYCLIC CO, V35

[2] RELATIVISTIC CALCULATION OF ANOMALOUS SCATTERING FACTORS FOR X-RAYS [J].