EFFECT OF VITAMIN-C AND VITAMIN-E ON TOXICITY AND MUTAGENICITY OF HEXAVALENT CHROMIUM IN RAT AND GUINEA-PIG

被引：45

作者：

CHORVATOVICOVA, D

GINTER, E

KOSINOVA, A

ZLOCH, Z

机构：

[1] RES INST HUMAN NUTR, CS-88030 BRATISLAVA, CZECHOSLOVAKIA

[2] RES INST PREVENT MED, BRATISLAVA, CZECHOSLOVAKIA

[3] CHARLES UNIV, INST HYG, CS-30599 PLZEN, CZECHOSLOVAKIA

来源：

MUTATION RESEARCH | 1991年 / 262卷 / 01期

关键词：

VITAMIN-C; VITAMIN-E; HEXAVALENT CHROMIUM; ANTIMUTAGENICITY; MICRONUCLEUS TEST; LIPOPEROXIDATION; (RAT); (GUINEA PIG);

D O I：

10.1016/0165-7992(91)90104-C

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effect of simultaneous pretreatment with vitamins C and E on the toxicity and mutagenicity of K2Cr2O7 in rats and guinea pigs was evaluated. Dietary pretreatment of Cr(VI)-intoxicated rats with ascorbic acid or alpha-tocopherol normalized vitamin C levels in lungs but not in kidneys. The synergistic preventive effect of both vitamins was confirmed in the production of lipoperoxides in Cr(VI)-intoxicated rats. Simultaneous administration of vitamins C and E in guinea pigs prevented the decrease of vitamin C levels provoked by the oxidative effects of Cr(VI). The results of the micronucleus test in bone marrow showed that it was vitamin C that caused the antimutagenic effect against bichromate, in both rats and guinea pigs. The effect of vitamin E was demonstrated only in an increase of the ratio of NCE to PCE, i.e., in a decrease of the cytotoxic but not the mutagenic effects of hexavalent chromium.

引用

页码：41 / 46

页数：6

共 14 条

[1]

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[2]

CHORVATOVICOVA D, 1989, BIOLOGIA, V44, P1033

[3]

CHORVATOVICOVA D, 1985, BIOLOGIA, V40, P651

[4]

GINTER E, 1982, INT J VITAM NUTR RES, V52, P55