THE RELATIVE BIOLOGICAL EFFECTIVENESS OF B-10-NEUTRON CAPTURE THERAPY FOR EARLY SKIN REACTION IN THE HAMSTER

被引：41

作者：

HIRATSUKA, J

FUKUDA, H

KOBAYASHI, T

KARASHIMA, H

YOSHINO, K

IMAJO, Y

MISHIMA, Y

机构：

[1] NATL INST RADIOL SCI, CHIBA 260, JAPAN

[2] HYOGO MED CTR ADULTS, KOBE 673, JAPAN

[3] SHINSHU UNIV, DEPT CHEM, MATSUMOTO 370, JAPAN

[4] KOBE UNIV, SCH MED,DEPT DERMATOL,CHUO KU, KOBE 650, JAPAN

[5] KYOTO UNIV, INST RES REACTOR, OSAKA 59004, JAPAN

来源：

RADIATION RESEARCH | 1991年 / 128卷 / 02期

关键词：

D O I：

10.2307/3578136

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The relative biological effectiveness (RBE) of 10B-neutron capture therapy (BNCT) on skin was analyzed using hamsters. The Kyoto University Research Reactor, which has a very low contamination of γ rays and fast neutrons, was used as a thermal neutron source. Boron-10-para-boronophenylalanine hydrochloride ([10B]BPA · HCl) was administered to the hamsters. The evolution and time course of early skin reactions were assessed. These reactions were compared with those produced by electron beams. The maximum safe skin doses (no more than moist desquamation) of BNCT and electron beams were established to be 11 and 21 Gy, respectively. The RBE at this single dose with BNCT was found to be 1.94, assuming that the RBE of the γ rays was 1.0 and each component of BNCT (mixed radiations) was simply additive.

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页码：186 / 191

页数：6

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