ENANTIOSPECIFIC SYNTHESIS OF 5'-NORARISTEROMYCIN AND ITS 7-DEAZA DERIVATIVE AND A FORMAL SYNTHESIS OF (-)-5'-HOMOARISTEROMYCIN

被引：59

作者：

SIDDIQI, SM ^{[1
]}

CHEN, X ^{[1
]}

SCHNELLER, SW ^{[1
]}

机构：

[1] UNIV S FLORIDA,DEPT CHEM,TAMPA,FL 33620

来源：

NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 3-4期

关键词：

D O I：

10.1080/07328319308017825

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Beginning with the treatment of the diacetate of cis-3,5-cyclopentenediol (5) with Pseudomonas cepacia lipase, (-)-5'-noraristeromycin (1) and (-)-7-deaza 5'-noraristeromycin (3) have been prepared. Subjecting 5 to treatment with porcine liver esterase led to an efficient preparation of a substituted cyclopentane precursor which, following literature precedence, can be converted into (-)-5'-homoaristeromycin (4).

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页码：267 / 278

页数：12

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