共 4 条
CYTOGENETIC STUDY OF 30 COLORECTAL ADENOMAS
被引:27
作者:
MULERIS, M
ZAFRANI, B
VALIDIRE, P
GIRODET, J
SALMON, RJ
DUTRILLAUX, B
机构:
[1] INST CURIE, BIOL SECT, CNRS, URA 620, F-75231 PARIS 05, FRANCE
[2] INST CURIE, MED & HOSP SECT, PARIS, FRANCE
关键词:
D O I:
10.1016/0165-4608(94)90006-X
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The cytogenetic analysis of 30 colorectal adenomas obtained from 24 patients is reported. Only normal karyotypes were observed in eight cases. Among the 22 adenomas with abnormal karyotypes, 15 showed clonal anomalies. Chromosome gains involving chromosomes 13, 20, 7, 9, and 12 were recurrently observed. Chromosome 18 was frequently lost or involved in translocations at bands q21-q22. More chromosome alterations were observed in the cases in which histologic examination revealed severe dysplasia or a carcinomatous component. These anomalies are discussed in relation to those described in colorectal adenocarcinoma.
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页码:104 / 108
页数:5
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