TC-99M LABELING OF BIS-OXIME LIGANDS

被引：3

作者：

JACKSON, GE ^{[1
]}

BYRNE, MJ ^{[1
]}

FAKIER, H ^{[1
]}

HUNTER, R ^{[1
]}

WOUDENBERG, M ^{[1
]}

机构：

[1] UNIV CAPE TOWN,DEPT NUCL MED,RONDEBOSCH 7700,SOUTH AFRICA

来源：

APPLIED RADIATION AND ISOTOPES | 1994年 / 45卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0969-8043(94)90201-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis and labelling of a new bis-amide-oxime ligand E,E-2,9-bis(hydroxyimino)-4,7-diaza-5,6-dioxodecane (AdO) with Tc-99m has been achieved. Protein binding, partition coefficient and tissue distribution of this complex and two related bis-amine-oxime ligands is reported. The biodistribution of the complexes are disappointing with only limited brain and myocardial uptake. Structures for the complex are postulated.

引用

页码：581 / 586

页数：6

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