DNA-DAMAGE INDUCED BY VACUUM AND SOFT-X-RAY PHOTONS FROM SYNCHROTRON-RADIATION

The recent development of irradiation systems using synchrotron radiation (SR) as a source is enabling researchers to obtain intense monochromatic photons having a narrow bandwidth in the vacuum-UV (VUV) and soft X-ray regions. We can thus systematically study the photon energy dependence of DNA damage formation in these energy regions. The photon energy dependence provides useful information about how energy-absorbing modes - excitations, so-called superexcitations, outer- and inner-shell ionizations - affect the type and amount of DNA damage. Furthermore, low energy electrons produced by low energy photons through photoelectric interactions are useful for studying how the electron energy affects the induction of DNA damage. A report is given on the present status of the SR irradiation systems in Japan as well as some results concerning the formation of DNA damage, in vitro and in vivo, by monochromatic photons in the VUV and soft Xray regions.