DNA-PLOIDY AND CLONAL SELECTION IN RAS PLUS MYC-INDUCED MOUSE PROSTATE-CANCER

被引:4
作者
GREENE, DR
TAYLOR, SR
AIHARA, M
YOSHIDA, K
EGAWA, S
PARK, SH
TIMME, TL
YANG, G
SCARDINO, PT
THOMPSON, TC
机构
[1] BAYLOR COLL MED,SCOTT DEPT UROL,HOUSTON,TX 77030
[2] BAYLOR COLL MED,DEPT CELL BIOL,HOUSTON,TX 77030
[3] BAYLOR COLL MED,DEPT PATHOL,HOUSTON,TX 77030
[4] BAYLOR COLL MED,DEPT RADIOL,HOUSTON,TX 77030
[5] VET AFFAIRS MED CTR,UROL RES LAB,HOUSTON,TX 77211
关键词
D O I
10.1002/ijc.2910600321
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
An important goal in prostate cancer research is to define specific molecular and cellular alterations that are associated with malignant progression. The mouse prostate reconstitution model is a relevant and useful system as it allows the study of early events in cancer progression under conditions where oncogene-initiated cells are surrounded by normal tissue. Using this model, activated ras and myc oncogenes are introduced into urogenital sinus cells via the recombinant retrovirus Zipras/myc 9. After 4 weeks' growth as subcapsular renal grafts, poorly differentiated carcinomas are produced in C57BL/6 mice. In this study we examined the temporal relationships between morphological alterations, growth, DNA ploidy status and clonal selection as determined by Southern blotting in ras + myc-initiated carcinomas. Nuclear image analysis demonstrated that the emergence of a cycling DNA tetraploid cell population strongly correlated with growth and histologic progression. These tightly linked events culminated in the outgrowth of mono- or oligoclonal cancer. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:395 / 399
页数:5
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