Slc39a13/Zip13: A Crucial Zinc Transporter Involved in Tooth Development and Inherited Disorders

被引：16

作者：

Fukada, Toshiyuki ^{[1
,2
]}

Asada, Yoshinobu ^{[3
]}

Mishima, Kenji ^{[4
]}

Shimoda, Shinji ^{[5
]}

Saito, Ichiro ^{[4
]}

机构：

[1] RIKEN, Res Ctr Allergy & Immunol, Lab Cytokine Signaling, 1-7-22 Suehiro, Yokohama, Kanagawa 2300045, Japan

[2] Osaka Univ, Grad Sch Med, Lab Allergy & Immunol, Suita, Osaka 5650871, Japan

[3] Tsurumi Univ, Sch Dent Med, Dept Pediat Dent, Yokohama, Kanagawa 2308501, Japan

[4] Tsurumi Univ, Sch Dent Med, Dept Pathol, Yokohama, Kanagawa 2308501, Japan

[5] Tsurumi Univ, Sch Dent Med, Dept Anat 1, Yokohama, Kanagawa 2308501, Japan

来源：

JOURNAL OF ORAL BIOSCIENCES | 2011年 / 53卷 / 01期

关键词：

Zinc transporter; Slc39a13; Zip13; BMP; TGF-beta; Smad; Ehlers-Danlos syndrome;

D O I：

10.2330/joralbiosci.53.1

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Zinc(Zn) is an essential trace element and it plays indispensable roles in cellular processes for embryonic and postnatal development in mammals. Zn deficiency causes growth retardation, reduced bone volume, dental decay, skin diseases, and other conditions. Zn homeostasis is tightly controlled by the action of Zn transporters and metallothioneins, which together intricately regulate the Zn concentration and distribution in cells. We recently investigated the role of the Zn transporter Slc39a13/Zip13 in mice and humans. Mice deficient in Zip13 show changes in the tooth, bone, and connective tissues, and impairments in BMP and TGF-beta signaling. A unique variant of Ehlers-Danlos syndrome(EDS) with hypodontia was found, in which Zip13 possesses a loss-of-function mutation, indicating that Zip13-mediated Zn homeostasis is crucial for tooth, bone and connective tissue development in mice and humans. In this review, we describe how Zn affects biological events especially in tooth development, with recent progress uncovering the roles of the Zn transporter Zip13 in mammalian health and diseases.

引用

页码：1 / 12

页数：12

共 83 条

[1] Msx homeobox gene family and craniofacial development [J].

Alappat, S ;

Zhang, ZY ;

Chen, YP .

CELL RESEARCH, 2003, 13 (06) :429-442

[2] Counting the zinc-proteins encoded in the human genome [J].

Andreini, C ;

Banci, L ;

Bertini, I ;

Rosato, A .

JOURNAL OF PROTEOME RESEARCH, 2006, 5 (01) :196-201

[3] Mouse zinc transporter 1 gene provides an essential function during early embryonic development [J].

Andrews, GK ;

Wang, HB ;

Dey, SK ;

Palmiter, RD .

GENESIS, 2004, 40 (02) :74-81

[4] Brief report: Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta [J].

Barnes, Aileen M. ;

Cliang, Weizhong ;

Morello, Roy ;

Cabral, Wayne A. ;

Weis, MaryAnn ;

Eyre, David R. ;

Leikin, Sergey ;

Makareeva, Elena ;

Kuznetsova, Natalia ;

Uveges, Thomas E. ;

Ashok, Aarthi ;

Flor, Armando W. ;

Mulvihill, John J. ;

Wilson, Patrick L. ;

Sundaram, Usha T. ;

Lee, Brendan ;

Marini, Joan C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (26) :2757-2764

[5]

Beighton P, 1998, AM J MED GENET, V77, P31, DOI 10.1002/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.3.CO

[6]

2-P

[7] Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly [J].

Belloni, E ;

Muenke, M ;

Roessler, E ;

Traverso, G ;

SiegelBartelt, J ;

Frumkin, A ;

Mitchell, HF ;

DonisKeller, H ;

Helms, C ;

Hing, AV ;

Heng, HHQ ;

Koop, B ;

Martindale, D ;

Rommens, JM ;

Tsui, LC ;

Scherer, SW .

NATURE GENETICS, 1996, 14 (03) :353-356

[8] AUTORADIOGRAPHIC STUDIES ON DISTRIBUTION OF ZINZ-65 IN MICE [J].

BERGMAN, B ;

SOREMARK, R .

JOURNAL OF NUTRITION, 1968, 94 (01) :6-&

[9] Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling [J].

Bruinsma, JJ ;

Jirakulaporn, T ;

Muslin, AJ ;

Kornfeld, K .

DEVELOPMENTAL CELL, 2002, 2 (05) :567-578

[10] Early iron-deficiency-induced transcriptional changes in Arabidopsis roots as revealed by microarray analyses [J].

Buckhout, Thomas J. ;

Yang, Thomas J. W. ;

Schmidt, Wolfgang .

BMC GENOMICS, 2009, 10

← 1 2 3 4 5 6 7 8 9 →