THE ROLE OF PHOSPHOLIPASE-A2 IN LIPID PEROXIDATION-INDUCED FALL OF MEMBRANE-POTENTIAL OF RAT-LIVER MITOCHONDRIA

被引：8

作者：

GOGVADZE, VG

BRUSTOVETSKY, NN

ZHUKOVA, AA

机构：

[1] Institute of Biological Physics, USSR Academy of Sciences, Pushchino

来源：

FEBS LETTERS | 1990年 / 264卷 / 02期

关键词：

Calcium; Lipid peroxidation; Mitochondria; Phospholipase A[!sub]2[!/sub;

D O I：

10.1016/0014-5793(90)80240-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cumene hydroperoxide (230 μM)-induced fall of the membrane potential takes place only in Ca2+ -loaded mitochondria. Inhibitor of phospholipase A2, P-bromphenacyl bromide prevents uncoupling of mitochondria, having no effect on the accumulation of lipid peroxidation products. © 1990.

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页码：168 / 170

页数：3

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