THE INFLUENCE OF NODAL CONSTRICTION ON CONDUCTION-VELOCITY IN MYELINATED NERVE-FIBERS

被引:27
作者
HALTER, JA [1 ]
CLARK, JW [1 ]
机构
[1] RICE UNIV,DEPT ELECT & COMP ENGN,HOUSTON,TX 77251
关键词
ANATOMY; COMPUTER SIMULATION; CONDUCTION VELOCITY; MATHEMATICS; MYELINATED NERVE FIBER; NEUROLOGICAL MODELS; NODE OF RANVIER;
D O I
10.1097/00001756-199301000-00023
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
MYELINATED nerve fibers exhibit a complex anatomy in the nodal region which includes a marked nodal-paranodal constriction and an intricate paranodal structure where the myelin sheath is separated from the axon by a narrow periaxonal space. In this study, a recently developed computational model of the mammalian myelinated nerve fiber based on electron microscopic data was employed to examine the effect of the nodal-paranodal axonal radius and periaxonal space width on the conduction of action potentials. These findings indicate that the nodal-paranodal constriction promotes higher conduction velocities by minimizing the component of the nodal capacity contributed by the paranodal axolemma. Model prediction of optimal nodal-paranodal radii is correlated with radii determined in experimental anatomical studies.
引用
收藏
页码:89 / 92
页数:4
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