MECHANISM OF INHIBITION OF IGE-DEPENDENT HISTAMINE-RELEASE FROM RAT MAST-CELLS BY PENASTEROL AND PENASTERONE

被引：9

作者：

TAKEI, M ^{[1
]}

UMEYAMA, A ^{[1
]}

SHOJI, N ^{[1
]}

ARIHARA, S ^{[1
]}

ENDO, K ^{[1
]}

机构：

[1] TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1995年 / 84卷 / 02期

关键词：

D O I：

10.1002/jps.2600840222

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Penasterol and penasterone, constituents of the Okinawan marine sponge Penares incrustans, dose-dependently inhibited anti-IgE-induced histamine release from rat mast cells. The concentrations of penasterol and penasterone required for 50% inhibition of anti-IgE-induced histamine release (IC50) were 0.5 and 1.5 mu M, respectively. Both compounds dose-dependently inhibited phospholipase A2 (PLA2) activity. Moreover, they inhibited anti-IgE-induced [H-3]arachidonic acid from rat mast cells. These results suggest that the mechanism of inhibition by these compounds of the histamine release induced by anti-IgE was through the inhibition of PLA2.

引用

页码：228 / 230

页数：3

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