EFFECTS OF CHRONIC D-AMPHETAMINE ON SOCIAL-BEHAVIOR OF RAT - IMPLICATIONS FOR AN ANIMAL-MODEL OF PARANOID SCHIZOPHRENIA

被引：44

作者：

GAMBILL, JD ^{[1
]}

KORNETSKY, C ^{[1
]}

机构：

[1] BOSTON UNIV, SCH MED, DEPT PSYCHIAT, BEHAV PHARMACOL, BOSTON, MA 02215 USA

来源：

PSYCHOPHARMACOLOGY | 1976年 / 50卷 / 03期

关键词：

D O I：

10.1007/BF00426835

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hooded rats in a social colony were given increasing daily doses of d-amphetamine up to 8 mg/kg. Time-lapse 16 mm cinematographically recorded behavior was analyzed for the following: grooming, feeding, sex, sleeping, resting, stereotypy, agonistic behavior, muricidal activity, and the location and movement of each rat. Subordinant rats receiving d-amphetamine actively withdrew from social interactions by retreating to strategically defensible locations in the environment. They remained hypervigilant of other rats and overreacted to their approaches by either fleeing or by defensively rearing and boxing. When the dominant rat received the maximum dose, it seemed totally oblivious to the other rats. The responses to drug treatment in subordinant rats may provide a model for the social behavior of frightened paranoid schizophrenics.

引用

页码：215 / 223

页数：9

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