The herpes family of viruses causes significant morbidity and mortality in patients infected with the human immunodeficiency virus (HIV). The most prevalent members of the herpes family in the HIV-infected population are cytomegalovirus, herpes simplex, and varicella-zoster. In the past year, more experience has been gathered regarding the treatment of these infections in the patient with acquired immunodeficiency syndrome (AIDS). In addition, the specter of clinically significant resistance to antiviral agents has been raised. New agents are being investigated which may have utility for these infections; more information is needed.