THE ORGANIZATION OF THE HUMAN-IMMUNOGLOBULIN-LAMBDA GENE LOCUS

被引：45

作者：

KAWASAKI, K

MINOSHIMA, S

SCHOOLER, K

KUDOH, J

ASAKAWA, S

DEJONG, PJ

SHIMIZU, N

机构：

[1] KEIO UNIV, SCH MED, DEPT MOLEC BIOL, SHINJUKU KU, TOKYO 160, JAPAN

[2] UNIV ARIZONA, DEPT MOLEC & CELLULAR BIOL, TUCSON, AZ 85721 USA

[3] ROSWELL PK CANC INST, DEPT HUMAN GENET, BUFFALO, NY 14263 USA

来源：

GENOME RESEARCH | 1995年 / 5卷 / 02期

关键词：

D O I：

10.1101/gr.5.2.125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To elucidate the complex structure of the human immunoglobulin lambda gene locus, a 1020-kb contig was constructed using 184 cosmid clones and one bacterial artificial chromosome (BAC) clone. A high-resolution physical map of this contig revealed that the entire lambda gene locus is 911 kb in length. It contains seven constant region (C-lambda) gene segments and 69 unique EcoRI-HindIII segments that hybridize to variable region gene (V-lambda) probes. The VpreB gene, BCRL4, and gamma-glutamyl transpeptidase gene (GGT)-like sequences are also located within the lambda gene locus. Hybridization analysis suggested that the lambda gene locus has undergone extensive amplification events in evolution.

引用

页码：125 / 135

页数：11

共 42 条

[1] CONSTRUCTION AND CHARACTERIZATION OF A YEAST ARTIFICIAL CHROMOSOME LIBRARY CONTAINING 7 HAPLOID HUMAN GENOME EQUIVALENTS
ALBERTSEN, HM
ABDERRAHIM, H
CANN, HM
DAUSSET, J
LEPASLIER, D
COHEN, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) : 4256 - 4260
[2] ANAND R, 1990, GEL ELECTROPHORESIS, P101
[3] THE ISOLATION OF A HUMAN IG V-LAMBDA GENE FROM A RECOMBINANT LIBRARY OF CHROMOSOME 22 AND ESTIMATION OF ITS COPY NUMBER
ANDERSON, MLM
SZAJNERT, MF
KAPLAN, JC
MCCOLL, L
YOUNG, BD
[J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (17) : 6647 - 6661
[4] THE HUMAN VPREB GENE IS LOCATED ON CHROMOSOME-22 NEAR A CLUSTER OF V-LAMBDA-1 GENE SEGMENTS
BAUER, SR
HUEBNER, K
BUDARF, M
FINAN, J
ERIKSON, J
EMANUEL, BS
NOWELL, PC
CROCE, CM
MELCHERS, F
[J]. IMMUNOGENETICS, 1988, 28 (05) : 328 - 333
[5] STRUCTURE AND PRE-B LYMPHOCYTE RESTRICTED EXPRESSION OF THE VPREB GENE IN HUMANS AND CONSERVATION OF ITS STRUCTURE IN OTHER MAMMALIAN-SPECIES
BAUER, SR
KUDO, A
MELCHERS, F
[J]. EMBO JOURNAL, 1988, 7 (01) : 111 - 116
[6] A REPERTOIRE OF MONOCLONAL-ANTIBODIES WITH HUMAN HEAVY-CHAINS FROM TRANSGENIC MICE
BRUGGEMANN, M
CASKEY, HM
TEALE, C
WALDMANN, H
WILLIAMS, GT
SURANI, MA
NEUBERGER, MS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) : 6709 - 6713
[7] ISOLATION AND REGIONAL LOCALIZATION OF 35 UNIQUE ANONYMOUS DNA MARKERS FOR HUMAN-CHROMOSOME 22
BUDARF, ML
MCDERMID, HE
SELLINGER, B
EMANUEL, BS
[J]. GENOMICS, 1991, 10 (04) : 996 - 1002
[8] A PANEL OF HUMAN CHROMOSOME-22-SPECIFIC SEQUENCE TAGGED SITES
COLLINS, JE
EVERETT, LA
BENTLEY, DR
DUNHAM, I
[J]. GENOMICS, 1992, 14 (04) : 1098 - 1103
[9] V-LAMBDA AND J-LAMBDA-C-LAMBDA GENE SEGMENTS OF THE HUMAN IMMUNOGLOBULIN-LAMBDA LIGHT CHAIN LOCUS ARE SEPARATED BY 14 KB AND REARRANGE BY A DELETION MECHANISM
COMBRIATO, G
KLOBECK, HG
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (06) : 1513 - 1522
[10] A MAP OF THE HUMAN-IMMUNOGLOBULIN V-H LOCUS COMPLETED BY ANALYSIS OF THE TELOMERIC REGION OF CHROMOSOME 14Q
COOK, GP
TOMLINSON, IM
WALTER, G
RIETHMAN, H
CARTER, NP
BULUWELA, L
WINTER, G
RABBITTS, TH
[J]. NATURE GENETICS, 1994, 7 (02) : 162 - 168

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