SERIAL EVOKED-POTENTIALS IN MULTIPLE-SCLEROSIS BOUTS - RELATION TO STEROID TREATMENT

被引：17

作者：

LAMANTIA, L ^{[1
]}

RITI, F ^{[1
]}

MILANESE, C ^{[1
]}

SALMAGGI, A ^{[1
]}

EOLI, M ^{[1
]}

CIANO, C ^{[1
]}

AVANZINI, G ^{[1
]}

机构：

[1] IST NAZL NEUROL C BESTA,SERV NEUROFISIOPATOL,I-20133 MILAN,ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1994年 / 15卷 / 07期

关键词：

MULTIPLE SCLEROSIS; EVOKED POTENTIALS; STEROIDS;

D O I：

10.1007/BF02339929

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Serial recordings of multimodal sensory (visual, acoustic and somatosensory) evoked potentials were made in 19 relapsing-remitting Multiple Sclerosis patients enrolled in a clinical trial designed to evaluate the efficacy of dexamethasone versts high- and low-dose methylprednisolone in acute multiple sclerosis bouts. electrophysiological and clinical evaluations were performed at the onset of therapy and until 6 months after the end of treatment. Using an arbitrary Evoked Potentials score that takes into account both latency and waveform alterations, we found a positive correlation between evoked potentials and clinical disability scores. Furthermore, different electrophysiological profiles were detected in the three therapeutic subgroups. Evoked potentials may be useful for monitoring acute Multiple Sclerosis bouts and evaluating the effect of therapy.

引用

页码：333 / 340

页数：8