ROLE OF ENDOTHELIN-1 IN BEAGLES WITH DEHYDROMONOCROTALINE-INDUCED PULMONARY-HYPERTENSION

被引：45

作者：

OKADA, M

YAMASHITA, C

OKADA, M

OKADA, K

机构：

[1] Department of Surgery, Division II, Kobe University School of Medicine, Kobe

[2] Department of Surgery, Division II, Kobe University School of Medicine, Chuo-ku, 650 Kobe City

来源：

CIRCULATION | 1995年 / 92卷 / 01期

关键词：

PULMONARY HEART DISEASE; ENDOTHELIN;

D O I：

10.1161/01.CIR.92.1.114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Although plasma levels of endothelin-1 (ET-1) increase in patients with pulmonary hypertension (PH), its role in PH is unknown. We investigated the contribution of endogenous ET-1 to cardiopulmonary changes in beagles with dehydromonocrotaline (DMCT)-induced PH. Methods and Results Eight 3-month-old beagles were given a single injection of 3 mg/kg DMCT via the right atrium. During the 8 weeks after injection, the mean pulmonary arterial pressure (PAP) and plasma ET-1 level increased significantly from 11.6+/-2.3 to 35.9+/-7.1 mm Hg and from 1.24+/-0.25 to 3.25+/-0.94 pg/mL, respectively. In controls, ET-1 infusion elevated the systemic arterial pressure (SAP) but did not alter PAP. In PH beagles, ET-1 infusion increased SAP, which was attenuated by FR139317 (an endothelin type [ET] A receptor antagonist), and produced a dose-dependent decrease in PAP, which was attenuated by RES-701-1. (an ETB receptor antagonist). In PH beagles, FR139317 infusion decreased PAP, and RES-701-1 infusion increased PAP. Sarafotoxin S6c (an ETB agonist) infusion decreased PAP in PH beagles. Conclusions These results suggest that endogenous ET-1 is elevated in PH disease and may mitigate PH by acting on ETB receptors.

引用

页码：114 / 119

页数：6

共 47 条

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