DRUG RELEASE FROM MICRODISPERSE SYSTEMS - A CRITICAL-REVIEW

被引：252

作者：

WASHINGTON, C

机构：

[1] Department of Pharmacy, University of Nottingham

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 58卷 / 01期

关键词：

Diffusion; Dissolution; Drug release; Microparticle; Nanoparticle;

D O I：

10.1016/0378-5173(90)90280-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The review article describes the current state of the art in the study of drug release from colloidal systems. Emphasis is placed on the practical aspects of obtaining kinetic release data from micron or submicron-sized carriers, which poses a range of experimental difficulties not encountered in the study of formulations with a larger panicle size. Potential sources of experimental error are discussed, and their effect on the interpretation of the data is examined. Mathematical models of drug release from such systems are also reviewed, and provide information which may be used to study formulation behaviour at a microscopic level. © 1990.

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页码：1 / 12

页数：12

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