UROMODULIN - A SPECIFIC INHIBITOR OF IL-1-INITIATED HUMAN T-CELL COLONY FORMATION

被引：11

作者：

WINKELSTEIN, A ^{[1
]}

MUCHMORE, AV ^{[1
]}

DECKER, JM ^{[1
]}

BLAESE, RM ^{[1
]}

机构：

[1] NCI,METAB BRANCH,BETHESDA,MD 20892

来源：

IMMUNOPHARMACOLOGY | 1990年 / 20卷 / 03期

关键词：

Interleukin; 2; T lymphocyte; Uromodulin;

D O I：

10.1016/0162-3109(90)90035-D

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Uromodulin, an 85 kDa naturally occurring immunosuppressant, was found to selectively and specifically inhibit the ability of IL-1 to induce colony responses by highly enriched suspensions of PHA-stimulated T lymphocytes. Dilutions of 1 × 10-8 M completely blocked the colony growth of T lymphocytes cultured with 50 U/ml IL-1; 1 × 10-9 M dilutions reduced scores by 83%. By contrast, uromodulin did not inhibit the responses of unseparated mononuclear cells, isolated T lymphocytes cultured with irradiated adherent cells, or stimulated T cells whose growth was initiated by either IL-2 or a soluble factor derived from Raji cells. © 1990.

引用

页码：201 / 206

页数：6

共 11 条

[1] UROMODULIN, AN IMMUNOSUPPRESSIVE PROTEIN DERIVED FROM PREGNANCY URINE, IS AN INHIBITOR OF INTERLEUKIN-1 [J].